Application of Genetic Analyses in Studies of Syndromic and Non-syndromic Cleft Lip and Palate
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Common Mutations of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in Non-Syndromic Cleft Lips and Palates Children in North-West of Iran
Introduction: Cleft lips and cleft palates are common congenital abnormalities in children. Various chromosomal loci have been suggested to be responsible the development of these abnormalities. The present study was carried out to investigate the association between the suspected genes (methylenetetrahydrofolate reductase [MTHFR] A1298C and C677T) that might contribute into the etiology of the...
متن کاملEffects of Tongue Plate on the Nasomaxillary Complex of Patients with Unilateral Cleft Lip and Cleft Palate
Background and aim: Cleft lip and cleft palate are among the most common orofacial abnormalities. Patients with these deformities commonly present with midface deficiency and need challenging treatment modalities that focus on improving the position of the maxilla. Tongue plate appliance is an intraoral device that has shown promising results in the treatment of growing patients with maxillary ...
متن کاملCleft lip and palate: Associated genetic and environmental factors
Cleft lip and palate are among the most common craniofacial anomalies of the human species causing considerable morbidity to affected individuals. The etiology of isolated or non-syndromic cleft lip and palate is complex and heterogeneous, and its occurrence is associated with the interaction of different genetic and environmental factors. To explore the genetic and environmental factors involv...
متن کاملAn update on the aetiology of orofacial clefts.
OBJECTIVE To review recent data on the aetiology of cleft lip and palate. DATA SOURCES MEDLINE literature search (1986-2003). STUDY SELECTION Literature and data on aetiology of cleft lip and palate using the following key words: 'cleft lip', 'cleft palate', 'aetiology', and 'genetics'. DATA EXTRACTION Relevant information and data were reviewed by the authors. DATA SYNTHESIS Cleft lip ...
متن کاملFamily history and socioeconomic risk factors for non-syndromic cleft lip and palate: a matched case-control study in a less developed country.
INTRODUCTION From an epidemiological point of view, non-syndromic orofacial clefts are the most common oral congenital deformities worldwide. OBJECTIVE Family histories were traced and socioeconomic risk factors were identified for non-syndromic cleft lip with or without cleft palate. MATERIAL AND METHODS A case-control study was carried out with 208 cases of non-syndromic cleft lip with or...
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تاریخ انتشار 2000